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Preclinical data reveal no special hazard for humans based on conventional studies of general pharmacologyrepeated dose toxicitygenotoxicityand carcinogenic potentialAngiotensin-converting enzyme inhibitorsas a classhave been shown to induce adverse effects on the late foetal developmentresulting in foetal death and congenital effectsin particular affecting the skullFoetotoxicityintrauterine growth retardation and patent ductus arteriosus have also been reportedThese developmental anomalies are thought to be partly due to a direct action of ACE inhibitors on the foetal renin-angiotensin system and partly due to ischaemia resulting from maternal hypotension and decreases in foetal-placental blood flow and oxygen/nutrients delivery to the foetus.

Zestril contains a medicine called lisinoprilThis belongs to a group of medicines called ACE inhibitors.

Too much sweatingdiarrheaor vomiting may cause loss of too much body waterdehydrationand increase your risk of lightheadednessReport prolonged diarrhea or vomiting to your doctorBe sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.

Dosage in patients with renal impairment should be based on creatinine clearance as outlined in Table 1 below.

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